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Under which condition is aspiration considered the preferred technique for creating a lesion?

A
  

in a deeper brain area

B
  

in an area of cerebral cortex

C
  

and irreversible lesion

D
  

in underlying white matter

Correct Answer: B

in an area of cerebral cortex

  • Aspiration lesions involve physically removing brain tissue using a suction pipette or cannula.
  • Preferred location: superficial cortical areas due to easy accessibility and visibility.
  • Rationale for cortex use:
    • Allows precise removal of gray matter without extensive damage to underlying structures.
    • Minimizes risk of injuring deep white matter tracts.
  • Not ideal for deep brain regions:
    • Reaching subcortical nuclei requires traversing healthy tissue, increasing collateral damage.
    • Alternatives like electrolytic or excitotoxic lesions are safer for deep targets.
  • Advantages of aspiration in cortex:
    • Immediate lesion confirmation visually.
    • Can selectively target layers of cortex.
  • Limitations:
    • Irreversible; not suitable where tissue sparing is critical.
    • Risk of bleeding or infection if improperly performed.

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